Avoid or Use Alternate Drug. Use Caution/Monitor. Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Applies only to oral form of both agents. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. Deferasirox chelates iron. Slow or stop the infusion if adverse reactions occur. Applies only to oral form of both agents. Either decreases levels of the other by inhibition of GI absorption. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. You may need extra iron because of blood loss during kidney dialysis. Applies only to oral form of both agents. Separate by 2 hr. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . Modify Therapy/Monitor Closely. Administer Venofer early during the dialysis session (generally within the first hour). Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Medically reviewed by Drugs.com. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. This information does not assure that this product is safe, effective, or appropriate for you. iron sucrose, captopril. Use Caution/Monitor. 5. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Keep all medical and lab appointments. Human studies not conducted. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Do not administer Venofer to patients with evidence of iron overload. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Applies only to oral form of both agents. Use Caution/Monitor. The dosage of Venofer is expressed in mg of elemental iron. This drug is available at the lowest co-pay. Applies only to oral form of both agents. This may be helped by giving the medication more slowly or at a lower dose. Modify Therapy/Monitor Closely. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Minor/Significance Unknown. Baloxavir may bind to polyvalent cations resulting in decreased absorption. The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). Applies only to oral form of both agents. Burns DL, Mascioli EA, Bistrian BR. Parenteral iron dextran therapy. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Either increases effects of the other by pharmacodynamic synergism. Venofer treatment may be repeated if necessary. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Slowing the infusion rate may alleviate symptoms. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Included in the iron dextran package insert. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Corrected Sodium and Effective Osmolality. Minor/Significance Unknown. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. May increase risk of hypotension. US residents can call their local poison control center at 1-800-222-1222. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose increases levels of calcium acetate by enhancing GI absorption. Use alternatives if available. Applies only to oral form of both agents. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Venofer may reduce the absorption of concomitantly administered oral iron preparations. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Where: Medicine concentration Amount of active substance per a given volume of your drug. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. You can further save the PDF or print it. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Separate by at least 4 hours. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. Applies only to oral form of both agents. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) Minor/Significance Unknown. This drug is available at a higher level co-pay. *Administer early during the dialysis session. Applies only to oral form of both agents. Applies only to oral form of both agents. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Minor/Significance Unknown. Use Caution/Monitor. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. Written by ASHP. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Applies only to oral form of both agents. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. 1) Ganzoni AM. Applies only to oral form of both agents. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Anemia; 2015: 763576. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Do not mix iron sucrose with other medications or TPN solution. Minor/Significance Unknown. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. Ferritin and transferrin are also recommended monitoring . Equations : Total body iron deficit (mg) = body weight (kg) x (target Hb - actual Hb in g/dL) x 2.4 + iron depot (mg)** [1, 2] Iron depot: 15 mg/kg for body weight less than 35 kg 500 mg for those with a body weight greater than or equal to 35 kg Ideal Body Weight (kg) =45.5 +2.3 * (height inches - 60 inches) [3] The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. World J Gastroenterol; 16(22): 27202725. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Your doctor will do laboratory tests to monitor your response. Either increases effects of the other by pharmacodynamic synergism. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Anemia caused by the depletion of iron is called iron deficiency anemia. Applies only to oral form of both agents. Our dosage calculator can help you with this as well. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. Copyright 1993-2021 iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Diagnosis and management of iron deficiency anaemia: a clinical update. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. Applies only to oral form of both agents. This drug is available at a middle level co-pay. The dosage of Venofer is expressed in mg of elemental iron. Venofer treatment may be repeated if necessary. Minor/Significance Unknown. Applies only to oral form of both agents. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Do not double the dose to catch up. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. May increase risk of hypotension. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Assure stable intravenous access to avoid extravasation. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Deferoxamine chelates iron. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Minor/Significance Unknown. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Separate dosing of tetracyclines from these products. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Avoid or Use Alternate Drug. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. This document does not contain all possible drug interactions. Avoid or Use Alternate Drug. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Objective. Use Caution/Monitor. Ferrlecit may also be administered undiluted as a slow intravenous injection (at a rate of up to 12.5 mg/min) per dialysis session. Use Caution/Monitor. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia.
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