Q. Hydrochloric acid reacts with a metal X to form a gas Y which burns with a 'pop' sound. Flush down drain while continuing to add cold water. It is actually quite simple - you neutralize it by turning it into salt water! volume2,pages 603611 (2020)Cite this article. Extended Data Fig. What are the chemical reactions that have NaCl (sodium chloride) as product? Burk, R. F. & Hill, K. E. Regulation of selenium metabolism and transport. Let's say that in this experiment we were using 0.5 M HCl and 0.1 M NaOH. The easiest way is to take water (H2 O) and add salt (NaCl). For panel b, minimum is non-tumor (-0.239), tumor (-0.6386), maximum is non-tumor (0.1874), tumor (1.0702) and median is non-tumor (0.0014), tumor (0.1402). 274, 1145511458 (1999). This means that your reactants will be sodium metal and hydrochloric acid, since these are the substances that are being transformed to form salt and hydrogen gas. InChI=1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2, InChI=1/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2, Except where otherwise noted, data are given for materials in their. wrote the manuscript with consultation from all of the authors. 3 d , the FeS/NC in DME electrolyte achieved remarkable reversible capacity of 520, 485, 455, 441, 427, 400, and 519 mAh g -1 at 0.1, 0.2, 0.5, 1.0, 2.0 and 5.0 A g -1 . Information about your use of this website will be shared with Google and other third parties. Like sodium hydroxide, baking soda can also work to neutralize hydrochloric acid. Values are relative to the cell lines expressing nontargeting (CTRL) guide, set at 1.0. The evaporation and crystallisation stages may be incomplete in the lesson time. To write a balanced chemical equation that describes this single replacement reaction, remember that, #overbrace("Na"_ ((s)) + "HCl"_ ((aq)))^(color(blue)("reactants")) -> overbrace("NaCl"_ ((aq)) + "H"_ (2(g)))^(color(darkgreen)("products"))# [2] Oxidation of this anion gives sodium selenate, Na2SeO4. Sodium hydroxide (NaOH) is formed by joining a single sodium atom (purple) to a hydroxide, OH, (red and white) together. Chemical structures and PMID of references which document the toxicity of each metabolite as a compound are shown. Similarly, sodium selenide is readily oxidized to polyselenides, a conversion signaled by off-white samples. Vol. Assuming that the students have been given training, the practical work should, if possible, start with the apparatus ready at each work place in the laboratory. Sodium Carbonate + Hydrochloric Acid - Na2CO3 + HCl - Molecular Rev. Here, we show that selenophosphate synthetase 2 (SEPHS2), an enzyme in the selenocysteine biosynthesis pathway, is essential for survival of cancer, but not normal, cells. Filling the burette, measuring out the alkali into the flask, and titrating it until it is neutralised takes about 20 minutes, with false starts being likely for many groups. For all panels, the measure of center is mean. Colorless, transparent, a caustic liquid that fumes in the air. 1, 10591066 (2002). Na 2 Se + 2 HCl H 2 Se + 2 NaCl. Each activity contains comprehensive information for teachers and technicians, including full technical notes and step-by-step procedures. In these crystals, each cube face becomes a hollow, stepped pyramid shape. c, Viability of cell lines following KO with guides against SEPHS2 for 11 days. and A.P. Peroxidase-like activity of nanocrystalline cobalt selenide and its For all panels, the measure of center is mean. and L.J.Z. Clin. Google Scholar. Olm, E. et al. Google Scholar. In this experiment students neutralise sodium hydroxide with hydrochloric acid to produce the soluble salt sodium chloride in solution. Is it known that BQP is not contained within NP? Extended Data Fig. However, this activity also becomes a liability for cancer cells because selenide is poisonous and must be processed by SEPHS2. https://orcid.org. For b, while trends can be seen, statistical comparisons were not carried out due to variability between cell lines. Isnt chemistry a wonderful science? [3] Alternatively, sodium selenide can be prepared by the reaction of gaseous hydrogen selenide with metallic sodium at 100 C. (Do not reuse the acid in the beaker this should be rinsed down the sink. Extended Data Fig. Carlisle, A.E., Lee, N., Matthew-Onabanjo, A.N. (2017) GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. The pentahydrate Na 2 SeO 3 (H 2 O) 5 is the most common water-soluble selenium compound. Cancer Cell 163, 506519 (2015). In practice it does not matter if the end-point is overshot, even by several cubic centimetres, but the aim is to find the proportions for a roughly neutral solution. Using a small funnel, pour a few cubic centimetres of 0.4 Mhydrochloric acid into the burette, with the tap open and a beaker under the open tap. 404, 115120 (2007). You wonder how to properly dispose of the strong hydrochloric acid. Burettes with pinchcocks of any type are not recommended; while cheap, they also are prone to leakage, especially in the hands of student beginners. For all panels, the measure of center is mean. copyright 2003-2023 Study.com. CAS ISSN 2522-5812 (online). KR870001937B1 - 7 3- , - Google Patents Neutralization by Metal Ions of the Toxicity of Sodium Selenide How can magnesium hydroxide be a strong base and be sparingly soluble at the same time? For all panels, *p<0.05 (students two-tailed t test). Sodium selenide reacts with acids to produce toxic hydrogen selenide gas. Then, 20 mL of 0.15 M sodium . 2 Further details of effects of SEPHS2 KO and overexpression in cells and in the MDA231 orthotopic xenograft. J. Biol. Annu. Salt solutions can be crystallised to produce solid salts. 17, 4564 (1994). About. b, Viability of control and SLC7A11 KO U251 cells treated with 12M of sodium selenite for 48hr. Hanahan, D. & Weinberg, R. Hallmarks of cancer: the next generation. Extended Data Fig. Yes, effectively. What are the chemical and physical characteristic of HCl (hydrogen chloride)? Each $\ce {H_2S}$ can form 4 hydrogen bonds with other $\ce {H_2S}$ molecules, whereas each $\ce {HCl}$ molecule can . JAMA 206, 591595 (1968). Throwing HCl directly onto the liquid HCl will neutralize the strong acid. designed the research. Cell 156, 317331 (2014). The 0.5 M and 0.1 M refer to the molarity. She holds teaching certifications in mathematics, biology and general science. This is achieved by including the corresponding solid phase into the equilibrium calculation. And in combination, our reaction products can be found at home in soup, brine, or salt water. The Se-O distances range from 1.67 to 1.72. Sign up for the Nature Briefing: Cancer newsletter what matters in cancer research, free to your inbox weekly. Now, lets acquaint ourselves with hydrochloricacid. 2a Determination of the reacting volumes of solutions of a strong acid and a strong alkali by titration. PubMedGoogle Scholar. As a result, when mixed with HCl (acid) it will react to form salt and water, both neutral substances. Read our privacy policy. d, Quantification of CC3 positive cells over total cells in CTRL and SEPHS2 deficient MDAMB231 and U251. Jiang, L. et al. Harrington, D. P. & Fleming, T. R. A class of rank test procedures for censored survival data. By using pH paper or a pH meter during the process, we can ensure that we end up with a neutral solution, which can be safely disposed of. This salt is a colourless solid. 35, 109134 (2015). And so a Chemist decided to reconcile the two hostile families and marry the lovers, to do everything to make sure that the reaction of sodium hydroxide with hydrochloric acid proceeded as planned. At this point, the salt water could be safely dumped down the drain. If crystallisation has occurred in shallow solution, with the crystals only partly submerged, hopper-shaped crystals may be seen. Scale bar=100m. and N.L. Discover a wealth of optimised experiments and demonstrations for your classroom. [6], Selenium is toxic in high concentrations. [8] The European Food Safety Authority reviewed the same safety question and set its UL at 300 g/day.[9]. To obtain Although, to be fair, we should note that only 1% of this water is suitable for consumption. Sanjana, N. E., Shalem, O. Sato, H., Tamba, M., Ishii, T. & Bannai, S. Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. Once the pH is neutral (a pH of 7), then we know that all of the hydrochloric acid has been turned into salt water. Even Romeo and Juliet has a happy ending there. SEPHS2 is required in cancer cells to detoxify selenide, an intermediate that is formed during selenocysteine biosynthesis. C CHEMISTRY; METALLURGY; C07 ORGANIC CHEMISTRY; C07J STEROIDS; C07J41/00 Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring; C07J Gene Identification, expression analysis and molecular docking of ATP sulfurylase in the selenization pathway of Cardamine hupingshanensis, Dietary supplementation with biogenic selenium nanoparticles alleviate oxidative stress-induced intestinal barrier dysfunction, CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma. Highly-concentrated acid causes severe burns if it encounters skin, mucous membranes or eyes, but is present in the human stomach at a concentration of around0.5%. Scale bar is 100m. An indicator can be added to show the end-point of the reaction. 10ae b, Percentages of Annexin V+/PI- and Annexin V+/PI+cells. Donating to our cause, you are not only help supporting this website going on, but also & Zhang, F. Improved vectors and genome-wide libraries for CRISPR screening. Breast Cancer Res. #color(white)(aaaaaaaaaa)color(red)("reaction arrow")#, The balanced chemical equation looks like this, #2"Na"_ ((s)) + 2"HCl"_ ((aq)) -> 2"NaCl"_ ((aq)) + "H"_ (2(g))#, 52977 views All of these are of course desirable traits to be developed in students, but there has to be some degree of basic competence and reliability before using a burette with a class. For panel c, minimum is non-tumor (1.10097), tumor (1.26305), maximum is non-tumor (3.85158), tumor (5.67272), and median is non-tumor (1.941515), tumor (2.86621). Learn more about Stack Overflow the company, and our products. 3 ). lessons in math, English, science, history, and more. Values are relative to the same cell lines expressing nontargeting guide (=1.0). The reaction is accompanied by a thermal effect, and the amount of heat released is 57.3kJ/mol. Number is an animal identifier number. You can help Wikipedia by expanding it. A strong acid, like HCl, cannot be disposed of by simply dumping it down the drain, as it is highly corrosive and will damage the pipes and destroy the sewage system by killing the microbes. Is it suspicious or odd to stand by the gate of a GA airport watching the planes? contracts here. Values are relative to the control cells treated with vehicle (=1.0). In order to neutralize, there must be the same number of moles of hydroxide ions as hydrogen ions. Cyclohexane Structure | Cyclohexane Density, Formula & Weight. organic chemistry - Would sodium salicylate dissolve in HCl Toxicol. ; NIH T32 CA130807-8 to M.E.S. Extended Data Fig. Sodium Selenide - an overview | ScienceDirect Topics Molarity is defined as the number of moles in a liter of solution. What are the chemical and physical characteristic of H2Se (Sodium selenide; Selenodisodium; Disodio selenide)? Sheehan, T. M. & Gao, M. Simplified fluorometric assay of total selenium in plasma and urine. ae, Representative flow cytometry data to address gating and quadrant strategy for FACS measurement of dying/dead cells. We start by slowly adding the 2.5 L of sodium hydroxide to the 0.5 L of hydrochloric acid. Synthesis of diselenides and selenides from elemental selenium A.E.C., N.L. 4 Expression of SEPHS2 in various types of tumor and normal tissues. Chemical Substance Systematic Name: Sodium selenide (Na2Se) IUPAC Name: Disodium selenide CAS Number: 1313-85-5 EPA Registry Name: Sodium selenide (Na2Se) Molecular Weight: 124.94 Molecular Formula: Na2Se Additional Metadata For more information about the substance, you may click one of the links below to take you to the relevant section: In order to properly dispose of acids, such as hydrochloric acid (a strong acid), we need to neutralize it by adding a base until its pH is neutral. By what magic are we doing this? In any laboratory where safety rules are observed and respected, alkalis and their ilk are kept strictly separate from acids and their ilk. [5], Sodium selenite has been proposed as an effective suicide agent. sodium chloride, NaCl(aq) hydrogen gas, H2(g) This means that your reactants will be sodium metal and hydrochloric acid, since these are the substances that are being transformed to form salt and hydrogen gas. Try refreshing the page, or contact customer support. Science 343, 8084 (2014). Laura has a Masters of Science in Food Science and Human Nutrition and has taught college Science. Cavalieri, R. R., Scott, K. G. & Sairenji, E. Selenite (75Se) as a tumor-localizing agent in man. Values are relative to each untreated cells (=1.0). One such reaction occurs between hydrochloric acid (HCl) and sodium hydroxide (NaOH). 19, 974983 (2002). The experiment is also part of the Royal Society of Chemistrys Continuing Professional Development course:Chemistry for non-specialists. In-situ synthesis of FeS/N, S co-doped carbon composite with So, what's the proper way to dispose of the hydrochloric acid? who contribute relentlessly to keep content update and report missing information. On this Wikipedia the language links are at the top of the page across from the article title. Catalysts are substances that speed up the pace (velocity) of a chemical reaction without being consumed or becoming part of the end product. We no further information about this chemical reactions. Baking soda is also classified as a base. Sodium hydroselenide dissolves in water or ethanol. You're just making a compound that's insoluble in water (salicylic acid), from one that isn't (sodium salicylate), using something else in the water (HCl), through ionic combination. Titration using a burette, to measure volumes of solution accurately, requires careful and organised methods of working, manipulative skills allied to mental concentration, and attention to detail. Hydrochloric acid has a pH of 3 and is a component of stomach acid. Use MathJax to format equations. The substances that are being transformed are called reactants and the substances that are being produced are called products. In order to tell when the sodium hydroxide has completely reacted with all of the hydrochloric acid, we just need to monitor the pH. Suzuki, K. T. & Ogra, Y. Metabolic pathway for selenium in the body: speciation by HPLC-ICP MS with enriched Se. Watching solutions evaporate can be tedious for students, and they may need another task to keep them occupied eg rinsing and draining the burettes with purified water. In the meantime, to ensure continued support, we are displaying the site without styles ; Searle Scholars Program, Rita Allen Foundation, Whitehall Foundation, Smith Family Foundation, and NIH/NIA DP2 AG067490-01 to P.L.G; and R01 CA229910 to L.M.S. Natl Acad. H2Se (Dihydrido selenium; Dihydrogen selenide; Hydrogen selenide; Selenium hydride; Dihydridoselenium), appearing at the end of the reaction. For all panels, *p<0.05 and **p<0.01 (students two-tailed t test). The volumes of acid and alkali solutions that react with each other can be measured by titration using a suitable indicator. ISEB Common Entrance Exam at 13+ Science: Study Guide & Test Prep, Psychological Research & Experimental Design, All Teacher Certification Test Prep Courses, Calculations of Hydrochloric Acid and Sodium Hydroxide, Process of Neutralizing Hydrochloric Acid, Physical & Chemical Properties of Elements: Metals, Nonmetals & Metalloids, Neutralizing Solutions with Sodium Hydroxide, ISEB Common Entrance Exam at 13+ Science Flashcards, UExcel Anatomy & Physiology: Study Guide & Test Prep, UExcel Microbiology: Study Guide & Test Prep, Human Anatomy & Physiology: Help and Review, NY Regents Exam - Earth Science: Help and Review, NY Regents Exam - Chemistry: Tutoring Solution, NY Regents Exam - Living Environment: Tutoring Solution, NY Regents Exam - Physics: Tutoring Solution, SAT Subject Test Chemistry: Tutoring Solution, SAT Subject Test Physics: Tutoring Solution, What is Sodium Hydroxide? This is because both products in the reaction are neutral. 18 October 2022, npj Science of Food Observe chemical changes in this microscale experiment with a spooky twist. This is a resource from thePractical Chemistry project, developed by the Nuffield Foundation and the Royal Society of Chemistry. The compound reacts with electrophiles to produce the selenium compounds. It's a precipitation reaction much like what you've probably learned before, just now in the class of organic salts, not metallic salts. What follows here assumes that teachers have judged the class to be capable of doing this experiment using a burette with reasonable expectation of success. Why is there a voltage on my HDMI and coaxial cables? Slowly add HCl to cold water until it reaches a 1:10 dilution of acid to water. USA 106, 1140011405 (2009). Comprehensive molecular portraits of invasive lobular breast. Because selenium is an essential element, sodium selenite is an ingredient in dietary supplements such as multi-vitamin/mineral products, but supplements that provide only selenium use L-selenomethionine or a selenium-enriched yeast. Xu, X. M. et al. Nature 575, 693698 (2019). Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. For all panels, *p<0.05, **p<0.01, and ***p<0.001 (students two-tailed t test). The studies on the selective synthesis of dialkyl selenide compounds 1 were presented. For example, pure water is neutral (pH of 7). f, Scanned image of a polystyrene microplate cover with PVP spots embedded with silver nitrate or lead acetate. It's a precipitation reaction much like what you've probably learned before, just now in the class of organic salts, not metallic salts. This is discussed further below, but what follows here assumes that you have judged the class to be capable of doing this experiment using a burette with reasonable expectation of success. A solid white or slightly yellowish powder; hygroscopic; corrodes many materials and organic substances including paper, skin, and even some metal;, dissolves in water, ethyl and methylalcohols. Accepting a proton in this case actually renders a molecule with lower energy than the negatively charged ion. 04 January 2022, Receive 12 digital issues and online access to articles, Get just this article for as long as you need it, Prices may be subject to local taxes which are calculated during checkout. Sodium selenide +1 compounds Selenium monochloride +4 compounds +4 compounds can exist in anions or cations . Sodium selenite is the inorganic compound with the formula Na2SeO3. g, In vivo tumor volume measurements for CTRL and SEPHS2 KO MDAMB231 orthotopic xenograft tumors. And now lets dive in even deeper, examining the reaction of sodium hydroxide and hydrochloric acid in the classification of chemicalreactions. Via a reaction between an acid and an alkali, we have turned the saddest of tragedies into a joyfulromance! These reactions release heat into the surroundings, resulting in an increase in temperature. For all panels **p<0.01, and ***p<0.001 (students two-tailed t test). This colourless solid is prepared by the reaction of selenium with a solution of sodium in liquid ammonia at 40 C. How are we supposed to turn hydrochloric acid into salt water? By thermal effect, it is exothermic. Carefully add the same volume of fresh hydrochloric acid as you used in stage 1, step 3,to another 25 (or 20) cm, Pour this solution into an evaporating basin. To understand the full extent of the tragedy, lets get better acquainted with them and examine the nature of sodium hydroxide and hydrochloric acid. c, SEPHS2 immunoblots from the cells used in b. Sodium hydroxide solution also reacts with the same metal X (on heating) to form the same gas Y. What are the chemical reactions that have HCl (hydrogen chloride) as reactant? The plate cover was scanned before (upper panel) and after (lower panel) selenide gas exposure for one min. How do you get out of a corner when plotting yourself into a corner. #color(white)(aaaaaaaaaaaaa/a)color(red)(uarr)# civil defense as a neutralizingsubstance; food industry to remove the skins from fruits and vegetables, in the manufacture of chocolate and cacao, and to soften olives and give them a darkcolor; cosmetics to remove keratinizedskin; ammonium. This should produce a white crystalline solid in one or two days. Well, neutralizing hydrochloric acid is easier than you might think. Like other alkali metal chalcogenides, this material is highly sensitive to water, easily undergoing hydrolysis to give mixtures of sodium biselenide (NaSeH) and hydroxide. Baking soda is often used to neutralize HCl in the event of a chemical spill. Physiol. Nature 551, 247250 (2017). Production and characterization of high-performance cobalt-nickel 24 chapters | Ferroptosis as a p53-mediated activity during tumour suppression. The reaction continues till the very end, until the reacting substances are completelyconsumed. Banerjee, B. D., Dwivedi, S. & Singh, S. Acute hydrogen selenide gas poisoning admissions in one of the hospitals in Delhi, India: case report. What is the thermochemical equation for the combustion of benzene? Nat. This behavior reflects that 10 M free selenide in excess over the metal kills the cells. f, Weight measurements for ex vivo CTRL and SEPHS2 KO MDAMB231 orthotopic xenograft tumors. Except where otherwise noted, data are given for materials in their, https://en.wikipedia.org/w/index.php?title=Sodium_hydroselenide&oldid=1108929754, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 7 September 2022, at 01:44. Acta Bioenerg. Chem. On this Wikipedia the language links are at the top of the page across from the article title. Article Identify those arcade games from a 1983 Brazilian music video. Menu. f, Viability of U251 cells treated with vehicle, 12M sodium selenite, and/or 10M Erastin for 72hr. These reactions typically take place between a strong acid and strong base. d, Total thiol quantification of 24hr conditioned media from control and SLC7A11 KO U251 cells. Students doing a titration experiment in a school science laboratory. That means you can actually reduce the concentration of insoluble salicylic acid by adding base, e.g. Explanation: The ideal environmental conditions for a reaction, such as temperature, pressure, catalysts, and solvent. Values are relative to that of the same cells treated with vehicle (=1.0). The right lower quadrant represents Annexin V positive and PI negative early dying cells. Wang, T., Wei, J. J., Sabatini, D. M. & Lander, E. S. Genetic screens in human cells using the CRISPRCas9 system. e, Total thiol quantification of 24hr conditioned media from control and SLC3A2 KO U251 cells. a, Viability of non-transformed (blue bars) and selenophilic cancer (red bars) cells under hypoxia (1% O2) for 48hr. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Med. In the cases of cadmium, copper, lead, mercury, silver and zinc, cells did not survive to exposure to such conditions ( Fig. What are the chemical reactions that have Na2Se (Sodium selenide; Selenodisodium; Disodio selenide) as reactant? You wont find the country of Chemistry on a world map, but it exists nonetheless. R.L., N.L., M.B.D. Electronic configuration. 6 Effects of hypoxia or nutrient-starved stresses on normal and selenophilic cancer cells. The concentration of the solution does not need to be made up to a high degree of accuracy, but should bereasonably close to the same concentration as the dilute hydrochloric acid, and less than 0.5 M. Dilute hydrochloric acid, HCl(aq) see CLEAPSSHazcardHC047a and CLEAPSSRecipe Book RB043. sodium metal, Na(s) hydrochloric acid, HCl(aq) and two substances are produced salt, i.e. Selenide gas was formed by mixing sodium selenide, at a final 50 mM concentration, into 3.7% hydrochloric acid solution. About Europe PMC; Preprints in Europe PMC Structural insights into the catalytic mechanism of Escherichia coli selenophosphate synthetase. A.E.C. Sodium selenide; Selenodisodium; Disodio selenide, Interesting Information Only Few People Knows, This system is delivered to you by Vietnamese students and teachers and D.K. Hydrochloric acid, a common substance used in the laboratory, cannot be disposed of by simply dumping it down the drain, as it is highly corrosive and will damage the pipes and destroy the sewage system by killing the microbes. Use this practical to investigate how solutions of the halogens inhibit the growth of bacteria and which is most effective, The physics of restoration and conservation, RSC Yusuf Hamied Inspirational Science Programme, How to prepare for the Chemistry Olympiad, Read our standard health and safety guidance, Unit 1: Structures, Trends, Chemical Reactions, Quantitative Chemistry and Analysis, 1.8 Acids, bases and salts: Indicators and pH, 1.8.18 demonstrate knowledge and understanding of how pure dry samples of soluble salts can be prepared by: adding excess insoluble substances to acid; adding alkali to acid, or vice versa, in the presence of an indicator; and repeating without indicator, 8. a, Validation of SEPHS2 RNA probe by RNAscope in situ hybridization in MDA231 cell pellet block samples. Chem. in equilibrium with solid phase Ba(OH)2:8H2O2, in equilibrium with solid phase Portlandite2, in equilibrium with solid phase Brucite2, in equilibrium with solid phase Calcite2, in equilibrium with solid phase Fe(OH)22, in equilibrium with solid phase Cd(OH)22, in equilibrium with solid phase Co(OH)22, in equilibrium with solid phase Zn(OH)2-c2, in equilibrium with solid phase Ni(OH)22, in equilibrium with solid phase Be(OH)22, in equilibrium with solid phase Cu(OH)22, in equilibrium with solid phase Pb(OH)22, in equilibrium with solid phase Cr(OH)3(a)2, in equilibrium with solid phase Hg(OH)22, Copyright 2012-2023 aqion.
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